Picture of Santyl


What is Santyl?

Santyl is an ointment is a sterile enzymatic debriding ointment. The enzyme collagenase contained in this ointment is derived from the fermentation by Clostridium histolyticium. It has the unique quality of digesting collagen in necrotic tissue.

Uses of Santyl

This ointment is used for debriding chronic dermal ulcers and severe burned areas. It helps wounded and dead tissues to get dissolved. Removal of dead tissues makes place for new ones. This action assists antibiotics to work faster and speed up the natural healing process of the body. It specifically targets necrotic materials to prevent the accumulation of harmful debris and harm to new tissues. It helps wounds to heal faster and allows granulation to proceed and epithelialization to occur.

Picture of Santyl

Picture 1 - Santyl

If you have any question about the Santyl ointment, consult your doctor. The medication is to be used only by the patient for whom it is prescribed. It is not to be shared with other people. You should also check with your doctor if your symptoms get worse.

Santyl Safety Guidelines

Certain medical conditions might interact with this ointment. Due to this reason, you should consult your doctor before applying this ointment.

You should not apply this ointment in the following cases:

  • If you are pregnant, planning to become pregnant or are breast feeding.
  • If you are on any prescribed or non-prescribed medicine, herbal products, or dietary supplementation.
  • If you have very poor health.
  • If you suffer from allergic reactions due to usage of certain medicines, foods or other substances.

Santyl Usage Instructions

Before taking this ointment, it is necessary for you to always go through the usage instructions to get the best results.

The steps for application are as follows:

Step 1

Make sure that you clean the wound with a saline solution to make the region sterile before applying the ointment. If a wound cleanser has been instructed by your doctor, apply it and then follow it up with saline rinse every time. If you are using an antibiotic powder, apply it to the injured area before applying the ointment.

Step 2

The application of the ointment is the next step. The emollient should be applied only to the wound or to a sterile gauze pad which is then applied to the wound and pressed down. It should not reach the healthy skin around the affected area.

Step 3

Do not apply the medication with bare fingers. Your doctor will recommend a sterile glove, gauze pad or applicator and you must stick to such instructions. The ointment to the affected area should be about the thickness of a nickel.

Step 4

If the wound has dried up or got hardened, the physician will advise you to moisten the wound while applying Santyl. Without proper moisturizing, the ointment will not work properly. Never use bandages or wound dressings that contain silver or iodine as these substances might react with the active ingredient present in this balm. Reapply the medication once a day or more frequently if the dressing becomes soiled.

Santyl Side Effects

Some users might experience certain side effects due to the usage of this ointment.

Image of Santyl

Picture 2 - Santyl Image

  • Pain, or a burning feeling, in the affected area.
  • Irritation or redness in the skin surrounding the affected region.
  • Injury and infection of the skin. Treatment of skin ulcers and burns cause breaking up and removing dead skin and tissue quite often which leads to greater risk of infection. The symptoms of serious infection are fever, fast breathing, fast heartbeat, warm skin and weakness.
  • Some might even experience very serious allergenic reactions which include rash, swelling, itching, severe dizziness and breathing troubles.

In all of the above cases, you should seek immediate medical attention.

Santyl Drug Interactions

There may be a few drug interactions with this ointment. However, you are advised not to start or stop any dosage suddenly without asking you doctor. Before using this medication, you should inform your doctor about any prescription or non-prescription herbal or antiseptic products that you are taking – especially those that contain lead, mercury and silver. Skin products contain heavy metals which may decrease the effect of the collagenase enzyme.

Santyl Storage Guide

Store the ointment at room temperature at or beneath 77 degrees F away from light and moisture. Do not freeze the ointment. Do not store the ointment in the bathroom. Keep all medicines away from the reach of children and pets. Do not flush the medicines down the toilet or pour them into a drain unless you are instructed. The medicine should be disposed of properly when it has expired or no longer needed.

Santyl Precautions

Before using this ointment, you must inform the doctor whether you have a past history of allergy associated to the medication, or whether you have other forms of allergy. You must also inform your doctor about your entire medical history before using this medication.








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